RIPPLE detects cell-type-anchored proximity gradients in spatial transcriptomics data by analyzing gene expression variation with distance to a query cell type.

bioRxiv · Jul 27, 2026 · PreprintBioinformatics

Tether-mediated extraction of myelinoid bodies by microglia and astrocytes can maintain myelin integrity

Erik Späte, Kieran P. Higgins, Yeonsu Kim, Carolina Mangana, Lina Komarek, Mohammadhossein Teymouri, Ulrike C. Gerwig, Svea Melzer, Boguslawa Sadowski, Torben Ruhwedel, Predrag Janjić, Bastiaan Lodder, Andrew J. Dwork, Maarten H. P. Kole, Anna M. Steyer, , Sandra Goebbels

The paper shows that microglia and astrocytes extract myelinoid bodies via tethers, preserving myelin sheath integrity through tension-driven scission and fusion.

bioRxiv · Dec 9, 2025 · PreprintNeuroscience

Purine nucleobases enhance CD8+ T cell effector function

Jakob‐Wendelin Genger, Ben Haladik, Alexander Lercher, Benedikt Agerer, Carolina Mangana, Fabian Amman, Csilla Viczenczová, Theresa Hohl, Anna Hofmann, Maximilian Koblischke, Bernhard Kratzer, Wentao Li, Kerstin Zinober, Felix Kartnig, Christina Schüller, , Andreas Bergthaler

This study identifies purine nucleobases as immunometabolites that enhance CD8+ T cell effector function by enabling a metabolic switch from de novo synthesis to salvage pathway.

bioRxiv · Aug 14, 2025 · PreprintImmunology

Conservation and divergence of myelin proteome and oligodendrocyte transcriptome profiles between humans and mice

Vasiliki‐Ilya Gargareta, Josefine Reuschenbach, Sophie B. Siems, Ting Sun, Lars Piepkorn, Carolina Mangana, Erik Späte, Sandra Goebbels, Inge Huitinga, Wiebke Möbius, Klaus‐Armin Nave, Olaf Jahn, Hauke B. Werner

The paper compares myelin proteome and oligodendrocyte transcriptome profiles between humans and mice, finding both conservation and divergence in specific proteins and genes.

eLife · Mar 23, 2022Peer-reviewedNeuroscience