Author

Thomas A McMurrough

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:CRISPR screen· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Brent E. SteadiD· 2 shared David R. EdgelliD· 2 shared Kurt W. LoedigeiD· 2 shared Alexa L. White· 1 shared Balpreet Dharni· 1 shared Gia-Khanh Luu· 1 shared Heyuan Qin· 1 shared Marjan Tavassoli· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersBiochemistry

Brent E. SteadORCID

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Author profile →

2 papers

Recent·Most cited

A buffer-tuning strategy to profile domain-specific activity of chimeric I-TevI/CRISPR gene editors in vitro

Kurt W. Loedige, Alexa L. White, Thomas A McMurrough, Brent E. Stead, David R. Edgell

This study shows how buffer conditions affect cleavage preferences of chimeric gene editors, revealing non-targeted cleavage in low salt environments.

Scientific Reports · Nov 28, 2025Peer-reviewedBiochemistry

Harnessing RNA-based DNA repair pathways for targeted gene editing

Nhan Huynh, Sin Kwon, Thomas A McMurrough, Kurt W. Loedige, Marjan Tavassoli, Weijuan Shao, Heyuan Qin, Gia-Khanh Luu, Balpreet Dharni, Olha Haydaychuk, Brent E. Stead, David R. Edgell

This paper introduces a method for targeted gene editing using RNA-templated DNA repair pathways in human cells, achieving high efficiency and fidelity.

bioRxiv · Apr 9, 2024 · PreprintMolecular Biology