Author

Thomas Bonacci

University of North Carolina at Chapel Hill

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 2 Research Focus:chromatin & epigenetic regulation· 1 Approach:comparative / phylogenetic analysis· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Derek L. BolhuisiD· 2 shared Michael J. EmanueleiD· 2 shared Nicholas Gene BrowniD· 2 shared Brandon L. MoueryiD· 1 shared Dalia FleifeliD· 1 shared Jeanette Gowen CookiD· 1 shared Xianxi WangiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiochemistry

Derek L. BolhuisORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Mechanisms of USP18 deISGylation revealed by comparative analysis with its human paralog USP41

Thomas Bonacci, Derek L. Bolhuis, Nicholas Gene Brown, Michael J. Emanuele

This study identifies molecular determinants of USP18's specificity for ISG15 through comparative analysis with its paralog USP41, revealing structural features essential for enzymatic activity.

Journal of Biological Chemistry · May 26, 2025Peer-reviewedBiochemistry

USP37 prevents unscheduled replisome unloading through MCM complex deubiquitination

Derek L. Bolhuis, Dalia Fleifel, Thomas Bonacci, Xianxi Wang, Brandon L. Mouery, Jeanette Gowen Cook, Nicholas Gene Brown, Michael J. Emanuele

This study identifies USP37 as a deubiquitinase that prevents premature replisome disassembly by deubiquitinating MCM7, ensuring genome stability and normal cell cycle progression.

Nature Communications · May 16, 2025Peer-reviewedCell Biology