Cancer BiologybioRxivPreprint
Dordaviprone/ONC201 Activation of the ClpP Mitochondrial Protease Inhibits the Growth of KRAS-Mutant Pancreatic Cancer and Overcomes RAS Inhibitor Resistance
Kristina Drizyte‐Miller, Seamus E. Degan, Ryan D. Mouery…·Channing J. Der
This study shows that ONC201 inhibits KRAS-mutant pancreatic cancer growth and overcomes resistance to RAS inhibitors by activating ClpP and altering metabolic pathways.
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