Community assessment of methods to deconvolve cellular composition from bulk gene expression
Brian S. White, Aurélien de Reyniès, Aaron M. Newman, Joshua J. Waterfall, Andrew E. Lamb, Florent Petitprez, Yating Lin, Rongshan Yu, Martin E. Guerrero-Gimenez, Sergii Domanskyi, Gianni Monaco, Verena Chung, Jineta Banerjee, Daniel S. Derrick, Alberto Valdeolivas, , Andrew J. Gentles
The paper evaluates deconvolution methods for inferring immune infiltration from bulk gene expression using a DREAM Challenge, finding that some community-contributed methods, especially deep learning-based ones, perform well.
Nature Communications · Aug 27, 2024Peer-reviewedBioinformatics