Jineta Banerjee

Towards Useful and Private Synthetic Omics: Community Benchmarking of Generative Models for Transcriptomics Data

The paper benchmarks generative models for synthetic bulk RNA-seq data, finding trade-offs between utility, biological preservation, and privacy risks across different methods.

Immortalization and Characterization of Schwann Cell Lines Derived from NF1 Associated Cutaneous Neurofibromas

The paper develops and characterizes semi-immortalized Schwann cell lines from NF1-associated cutaneous neurofibromas to aid in studying and developing therapies for NF1.

Integrated genomic analysis of NF1-associated peripheral nerve sheath tumors: an updated biorepository dataset

The paper provides an integrated genomic analysis of NF1-associated peripheral nerve sheath tumors using RNAseq and WES data from 73 and 114 samples, respectively, accessible via the NF Data Portal.

Community assessment of methods to deconvolve cellular composition from bulk gene expression

The paper evaluates deconvolution methods for inferring immune infiltration from bulk gene expression using a DREAM Challenge, finding that some community-contributed methods, especially deep learning-based ones, perform well.

CX3CL1 action on microglia protects from diet-induced obesity by restoring POMC neuronal excitability and melanocortin system activity impaired by high-fat diet feeding

This study shows that CX3CL1 reduces diet-induced obesity by restoring POMC neuron function and melanocortin signaling through microglial modulation.

Microglial inflammatory activation paradoxically improves glucose tolerance during diet-induced obesity

This study shows that microglial inflammatory activation improves glucose tolerance during diet-induced obesity, independent of body weight changes.

Integrative analysis identifies candidate tumor microenvironment and intracellular signaling pathways that define tumor heterogeneity in NF1

The paper uses statistical and machine learning methods to analyze NF1 tumor genomic data, identifying key signaling pathways and molecular features associated with different tumor types and potential drug targets.