Gianni Monaco

USP8 Controls Proteostasis Pathways in B Cells and Multiple Myeloma

This study investigates the role of USP8 in B-cell development and multiple myeloma, showing its impact on proteostasis and identifying potential therapeutic strategies.

Streptococcal meningoencephalitis dynamically shapes developmental monocyte and macrophage trajectories in the CNS

This study shows that streptococcal meningoencephalitis alters monocyte and macrophage dynamics in the dura by shifting their origin from skull bone marrow to peripheral sources and increasing MDP-Mo-derived cells.

Tissue imprinting defines functional mosaic of dermal macrophages

This study shows that dermal macrophages can maintain functional diversity without monocyte replenishment, but require monocytes during bacterial infections.

Community assessment of methods to deconvolve cellular composition from bulk gene expression

The paper evaluates deconvolution methods for inferring immune infiltration from bulk gene expression using a DREAM Challenge, finding that some community-contributed methods, especially deep learning-based ones, perform well.

Contrasting contribution of embryo- and postnatally-derived brain-resident macrophages in sustaining sleep-wake circuitry

This study shows that embryonic and postnatally-derived brain macrophages have distinct roles in regulating sleep-wake cycles and synaptic balance, with postnatal repopulation failing to restore normal sleep patterns.