Medulloblastoma-Associated KBTBD4 Mutations Disrupt PP2A-A Orphan Quality Control
Regina Baur, Laura A. Hehl, Gajanan J. Sathe, Thomas Lunardi, Jonathan Schneider, Anna-Sophia Krebs, Juan Carlos Silva, Diane L. Haakonsen, Sebastian M. Waszak, Joachim Lingner, Alessio Ciulli, Michael Rapé, Nicolas H. Thomä
This study identifies PP2A-A as a target of CRL3KBTBD4, showing that KBTBD4 mutations disrupt PP2A quality control and contribute to medulloblastoma by altering phospho-dependent signaling.
bioRxiv · Mar 3, 2026 · PreprintCell Biology