Novel Small Molecules Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein Protect Against Diverse α-Synuclein Mediated Dysfunctions
Gergely Tóth, Thomas Neumann, Amandine Berthet, Eliezer Masliah, Brian J. Spencer, Jiahui Tao, Michael F. Jobling, Shyra J. Gardai, Carlos W. Bertoncini, Nunilo Cremades, Michael P. Bova, Stephen J. Ballaron, Xiao-Hua Chen, Wenxian Mao, Phuong Trang Nguyen, , Lisa McConlogue
This study identifies small molecules that target the intrinsically disordered ensemble of α-synuclein, showing they can inhibit misfolding, restore phagocytosis, and block cellular transmission of α-synuclein.
Scientific Reports · Nov 18, 2019Peer-reviewedNeuroscience