Eliezer Masliah

PRISM-M: A Recurrent Framework for the Formation of Stable Internal Neural Models

PRISM-M is a recurrent framework that simulates how neural representations integrate into stable models, showing context-dependent shifts and predictive accuracy in simulations and fMRI data.

Genome-wide association study identifies a new susceptibility locus in PLA2G4C for Multiple System Atrophy.

This study identifies a new susceptibility locus, PLA2G4C, for Multiple System Atrophy through a genome-wide association study and functional analysis of a risk variant.

Identification of a sex-specific genetic signature in dementia with Lewy bodies: a meta-analysis of genome-wide association studies

This paper performs a large meta-analysis of GWAS in dementia with Lewy bodies, identifying sex-specific genetic risk signals and highlighting the need for larger cohorts.

Characterization of altered molecular mechanisms in Parkinson disease through cell type-resolved multi-omics analyses

This study identifies cell-type-specific dysregulated cis-regulatory elements and target genes in Parkinson's disease using multi-omic analyses of single-cell transcriptomes and epigenomes.

Specific Detection of Endogenous S129 Phosphorylated α-Synuclein in Tissue Using Proximity Ligation Assay

The paper develops a PLA method to specifically detect endogenous pS129 α-synuclein in tissue with low background and high specificity.

Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into the complex genetic architecture

This paper identifies five new genetic risk loci for Lewy body dementia through whole-genome sequencing and shows shared risk profiles with Alzheimer’s and Parkinson’s disease.

Novel Small Molecules Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein Protect Against Diverse α-Synuclein Mediated Dysfunctions

This study identifies small molecules that target the intrinsically disordered ensemble of α-synuclein, showing they can inhibit misfolding, restore phagocytosis, and block cellular transmission of α-synuclein.

Genetic modifiers of risk and age at onset in GBA associated Parkinson disease and Lewy body dementia

The paper identifies genetic modifiers of risk and age at onset in GBA-associated Parkinson disease and Lewy body dementia using large case-control datasets and genome-wide association studies.

Heritability and genetic variance of dementia with Lewy bodies

This study estimates the heritability of dementia with Lewy bodies (DLB) and finds it to be higher than previous estimates, with low variance explained by polygenic risk scores from Parkinson's or Alzheimer's disease.

Amyloid accumulation drives proteome-wide alterations in mouse models of Alzheimers disease like pathology

The paper identifies proteome-wide changes in mouse models of Alzheimer's disease, highlighting ApoE dysregulation and synaptic protein loss.

Gene expression patterns associated with neurological disease in HIV infection

The paper uses GSEA to analyze gene expression patterns in HIV-infected patients with and without neurocognitive impairments, finding that neuroinflammation and white matter dysfunction precede NCI.