Developmental BiologybioRxivPreprint
Prickle and Ror modulate Dishevelled-Vangl interaction to regulate non-canonical Wnt signaling during convergent extension
Hwa‐seon Seo, Deli Yu, Ivan Aleksandrovich Popov…·Jianbo Wang
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Howard Hughes Medical InstituteORCID 0000-0002-3016-1249Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
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Hwa‐seon Seo, Deli Yu, Ivan Aleksandrovich Popov…·Jianbo Wang
Jiahui Tao, Amandine Berthet, Y. Rose Citron…·Lisa McConlogue
This study identifies a novel non-canonical mechanism by which Hsp70 blocks α-synuclein oligomer formation, independent of ATP and the typical substrate-binding cleft.
Gergely Tóth, Thomas Neumann, Amandine Berthet…·Lisa McConlogue
This study identifies small molecules that target the intrinsically disordered ensemble of α-synuclein, showing they can inhibit misfolding, restore phagocytosis, and block cellular transmission of α-synuclein.