Phuong Trang Nguyen

This study identifies distinct malignant cell states and myeloid glutamate signaling in aggressive pancreatic neuroendocrine tumors, linking them to poor clinical outcomes and therapeutic vulnerabilities.

This study identifies Pdgfd-Pdgfrb signaling as a driver of perineural invasion in pancreatic cancer by promoting cancer cell invasiveness and nerve engagement.

This study identifies a nuclear branched-chain amino acid catabolism pathway in pancreatic cancer that regulates histone propionylation and gene expression.

This study identifies β-neurexins as presynaptic proteins that bind to α-synuclein preformed fibrils, impairing presynaptic organization and contributing to synucleinopathy pathology.

This study identifies small molecules that target the intrinsically disordered ensemble of α-synuclein, showing they can inhibit misfolding, restore phagocytosis, and block cellular transmission of α-synuclein.