Primary cilia promote EMT-induced triple-negative breast tumor heterogeneity and resistance to therapy
Camille E. Tessier, Jennifer Derrien, Aurore M. M. Dupuy, Thomas Pelé, Martin Moquet, Julie Roul, Elise Douillard, Camille El Harrif, Xavier Pinson, Matthieu Le Gallo, Florence Godey, Patrick Tas, Roselyne Viel, Eloïse M. Grasset, Claude Prigent, , Vincent J. Guen
This study shows primary cilia in TNBC cells contribute to chemoresistance by supporting EMT-driven heterogeneity and stemness, and inhibiting ciliogenesis reduces this resistance.
EMBO Molecular Medicine · Aug 26, 2025Peer-reviewedCancer Biology