Expanding the genetic code with diverse backbone structures across diverse sequence contexts
Carlos Piedrafita, A. D. Dickson, Daniel Richter, Caroline Weber, Thomas S. Elliott, Ziqi Liu, Fan Zhang, Yichen Li, Daniel L. Dunkelmann, Tomos E. Morgan, Kim C. Liu, Jason W. Chin
This paper expands the genetic code by incorporating non-canonical monomers into proteins using evolved tRNAs and orthogonal synthetases, enabling broader sequence context compatibility.
bioRxiv · Apr 17, 2026 · PreprintSynthetic Biology