Kim C. Liu

This paper expands the genetic code by incorporating non-canonical monomers into proteins using evolved tRNAs and orthogonal synthetases, enabling broader sequence context compatibility.

This paper introduces an improved orthogonal replication system in E. coli that enables rapid gene evolution with high mutation rates and demonstrates its application in evolving ethanol assimilation pathways.

This study maps DNA supercoiling and chromatin interactions during human stem cell differentiation, showing that gene activation increases negative supercoiling and correlates with enhanced DNA contacts.

This paper describes the creation of a synthetic Escherichia coli strain with a 57-codon genetic code by recoding 105 codons in a 4 Mb synthetic genome.

This paper demonstrates enzyme-free, sequence-dependent aminoacylation of RNA mimics, showing that terminal trinucleotides control aminoacylation selectivity.