Author

Thomas Walne

University of Sheffield

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Nan LiiD· 2 shared Ruth H. ThompsoniD· 2 shared Afzaal Tufail· 1 shared Alexander Breitweiser· 1 shared Carl SmytheiD· 1 shared Laura MapleiD· 1 shared Lydia Ellis· 1 shared Priya Lata· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 24 mutual co-author links

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2 shared papersCell Biology

Nan LiORCID

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2 papers

Recent·Most cited

Defective transcription in UPF1-deficient cells safeguards against replication stress, driving drug resistance

Thomas Walne, Laura Maple, Lydia Ellis, Nan Li, Carl Smythe, Ruth H. Thompson

This study shows that UPF1 deficiency in cancer cells causes replication stress but also drug resistance by reducing replication fork stalling and DNA repair pathway activation.

bioRxiv · May 22, 2025 · PreprintCell Biology

A SOD1-dependent mitotic DNA damage checkpoint

Rachel Gatenby, Nan Li, Priya Lata, Thomas Walne, Afzaal Tufail, Alexander Breitweiser, Ruth H. Thompson

This study identifies SOD1 as a key factor in mitotic DNA damage response, showing it mediates mitotic delay and DNA repair, with distinct pathways for repair or progression.

bioRxiv · Oct 26, 2022 · PreprintMolecular Biology