Author

Laura Maple

University of SheffieldORCID 0000-0002-1068-2143Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Carl SmytheiD· 1 shared Lydia Ellis· 1 shared Nan LiiD· 1 shared Ruth H. ThompsoniD· 1 shared Thomas Walne· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 10 mutual co-author links

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1 shared paperCell Biology

Carl SmytheORCID

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1 paper

Recent·Most cited

Defective transcription in UPF1-deficient cells safeguards against replication stress, driving drug resistance

Thomas Walne, Laura Maple, Lydia Ellis, Nan Li, Carl Smythe, Ruth H. Thompson

This study shows that UPF1 deficiency in cancer cells causes replication stress but also drug resistance by reducing replication fork stalling and DNA repair pathway activation.

bioRxiv · May 22, 2025 · PreprintCell Biology