Cytokine-induced memory-like responses in endothelial cells link chronic inflammation to vascular disease risk
Kieu T. T. Le, Nick Keur, Heleen H. T. Middelkamp, Thuy Linh Do, Albert van den Berg, Valeria V. Orlova, Leo A. B. Joosten, Mihai Gheorghe Netea, Cisca Wijmenga, Iris H. Jonkers, Sebo Withoff, Andries D. van der Meer, Vinod Kumar
This study shows that repeated cytokine exposure in endothelial cells induces memory-like responses, linking chronic inflammation to vascular disease risk through persistent transcriptional and epigenetic changes.
Molecular Omics · Oct 14, 2025Peer-reviewedMolecular Biology