Vinod Kumar

Cytokine-induced memory-like responses in endothelial cells link chronic inflammation to vascular disease risk

This study shows that repeated cytokine exposure in endothelial cells induces memory-like responses, linking chronic inflammation to vascular disease risk through persistent transcriptional and epigenetic changes.

Trans-eQTL mapping prioritises USP18 as a negative regulator of interferon response at a lupus risk locus

The paper identifies USP18 as a negative regulator of interferon response at a lupus risk locus through trans-eQTL analysis in lymphoblastoid cell lines.

Single-Cell Transcriptomics Unveils Skin Cell Specific Antifungal Immune Responses and IL-1Ra- IL-1R Immune Evasion Strategies of Emerging Fungal Pathogen Candida auris

This study uses single-cell transcriptomics to identify immune responses and IL-1Ra-IL-1R evasion strategies in C. auris skin infection.

In vitro host transcriptomics during Cryptococcus neoformans, Cryptococcus gattii, and Candida albicans infection of South African volunteers

The paper compares the transcriptional responses of immune cells to three fungal pathogens in vitro, finding distinct expression patterns and a weaker response to cryptococcal stimuli.

cis-eQTL mapping of TB-T2D comorbidity elucidates the involvement of African ancestry in TB susceptibility

This study identifies ancestry-specific eQTLs in TB-T2D patients using cis-eQTL mapping, revealing variants associated with gene expression that could guide therapeutic targets in African populations.

Integration of Candida albicans-induced single-cell gene expression data and circulatory protein concentrations reveal genetic regulators of inflammation

The paper integrates single-cell gene expression and circulatory protein data to identify genetic regulators of inflammation in response to Candida albicans.

Impact of rare and common genetic variation in theInterleukin-1 pathway for human cytokine responses

This study identifies associations between rare and common genetic variants in the IL-1 pathway and cytokine responses to various stimuli in healthy individuals.

Systematic prioritization of candidate genes in disease loci identifies TRAFD1 as a master regulator of IFNγ signalling in celiac disease

The paper identifies TRAFD1 as a master regulator of IFNγ signalling in celiac disease by systematically prioritizing candidate genes in disease loci using multiple computational methods.

Deconvolution of bulk blood eQTL effects into immune cell subpopulations

The paper introduces Decon2, a method to deconvolute bulk blood eQTL effects into immune cell subpopulations, showing high concordance with experimental and single-cell studies.