Leo A. B. Joosten

This study uses multi-omics clustering to identify three immunological endotypes in HIV patients, linking them to distinct HIV reservoir sizes and immune mechanisms.

This study shows that HIV persistence accelerates immune aging in treated individuals, while certain antiretroviral drugs reduce it.

This study shows that repeated cytokine exposure in endothelial cells induces memory-like responses, linking chronic inflammation to vascular disease risk through persistent transcriptional and epigenetic changes.

The paper investigates immune correlates of early Mtb clearance in TB household contacts, finding that BCG vaccination is linked to enhanced innate immune responses rather than adaptive immunity.

This study investigates how DNA methylation changes after BCG vaccination influence cytokine responses and identifies epigenetic pathways mediating genetic effects on immune responses.

This study identifies an adhesion-signalling mediated cell-state in HNSCC that drives drug tolerance, with a predictive transcriptional signature and functional validation.

The paper identifies a circulating transcriptomic biomarker in blood that correlates with FSHD clinical severity and validates it in muscle tissue.

This study explores the physiological significance of genetic variants associated with COVID-19 severity using clinical, immunological, and multi-omics data from large cohorts, identifying pathways for prevention and therapy.

This study examines how immune-related traits evolved in ancient and modern European populations, finding that the Neolithic transition influenced cytokine production and disease susceptibility.

This study identifies associations between rare and common genetic variants in the IL-1 pathway and cytokine responses to various stimuli in healthy individuals.

The paper introduces Decon2, a method to deconvolute bulk blood eQTL effects into immune cell subpopulations, showing high concordance with experimental and single-cell studies.

This study investigates the role of ABCG2 variants in gout progression from hyperuricemia, finding a stronger association with gout than with urate levels.