Valeria V. Orlova

This study uses a human cardioid injury platform to investigate immune-ECM-cardiomyocyte interactions in fetal cardiac repair, identifying key signaling pathways and cellular behaviors involved in regeneration.

STRAIGHT-IN Dual enables efficient, single-copy integration of two DNA payloads into hiPSCs, improving genetic engineering for synthetic biology applications.

This study shows that endothelial cells enhance doxorubicin-induced cardiotoxicity in co-cultures with cardiomyocytes, challenging the focus on cardiomyocytes alone.

This study develops a patient-specific vessel-on-chip model of abdominal aortic aneurysms, showing preserved pathological features and pro-inflammatory responses in vitro.

This study shows that repeated cytokine exposure in endothelial cells induces memory-like responses, linking chronic inflammation to vascular disease risk through persistent transcriptional and epigenetic changes.

The paper develops a tunable in vitro model to study ALK1's role in HHT by inducing ALK1 in ACVRL1-null hiPSC-derived endothelial cells, showing threshold-dependent restoration of endothelial function.

This paper describes a method to create microvasculature models using photolithography and hydrogel patterning, enabling rapid and tunable fabrication of perfusable vascular structures from stem cell-derived endothelial cells.

The paper identifies ETV2 dynamics in hiPSC-derived cardiac lineages using single-cell RNA-seq and a fluorescent reporter, revealing distinct subpopulations for endothelial and cardiomyocyte specification.