Satiation is associated with OGT-dependent regulation of excitatory synapses.
Mario Pérez Del Pozo, Manish Bhattacharjee, Anushree Tripathi, Thyra Boafo, Sabrina Galizia, Paolo Medini, Michael Druzin, Olof Lagerlöf
This study shows that OGT regulates excitatory synaptic plasticity in PVN CaMKII neurons, linking metabolic state to satiation signaling through changes in synaptic input resistance and activity during feeding and hunger.
bioRxiv · Sep 2, 2025 · PreprintNeuroscience