Molecular BiologyJCI InsightPeer-reviewed
Disruption of Prostaglandin F2α Receptor Signaling Attenuates Fibrotic Remodeling and Alters Fibroblast Population Dynamics in A Preclinical Murine Model of Idiopathic Pulmonary Fibrosis
L. Raposo Rodríguez, Soon Yew Tang, Willy Roque Barboza…·Michael Francis Beers
This study shows that disrupting PGF2α receptor signaling reduces fibrosis in a mouse model of IPF by altering fibroblast dynamics and reducing fibrotic endpoints.
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