Soon Yew Tang

The Regulation of COX-2, ABCA1 and ABCG1 by the lncRNA PACERR links the inflammatory response and cholesterol homeostasis

This paper identifies PACERR as a lncRNA that regulates COX-2 and cholesterol transport genes, linking inflammation and cholesterol homeostasis through distinct mechanisms in response to HDL and LPS.

Role of IL10 signaling in the circadian control of host response to Influenza infection

The paper investigates how IL-10 signaling interacts with circadian rhythms to influence the host response to influenza infection, finding that blocking IL-10 signaling abolishes time-of-day-specific protection.

Cyclooxygenase-2 disruption predisposes to heart failure with preserved ejection fraction

This study shows that COX-2 deletion or inhibition leads to heart failure with preserved ejection fraction in zebrafish, mice, and humans.

Disruption of the PGE2 synthesis / response pathway restrains atherogenesis in programmed cell death-1 (Pd-1) deficient hyperlipidemic mice

This study shows that disrupting the PGE2 synthesis or response pathway reduces atherogenesis in PD-1 deficient hyperlipidemic mice through different immune mechanisms.

Disruption of Prostaglandin F2α Receptor Signaling Attenuates Fibrotic Remodeling and Alters Fibroblast Population Dynamics in A Preclinical Murine Model of Idiopathic Pulmonary Fibrosis

This study shows that disrupting PGF2α receptor signaling reduces fibrosis in a mouse model of IPF by altering fibroblast dynamics and reducing fibrotic endpoints.

Loss of Circadian Protection in Adults Exposed to Hyperoxia as Neonates

This study shows neonatal hyperoxia disrupts circadian protection from Influenza A in adulthood through lung intrinsic clock mechanisms, not viral burden.