Garret A. FitzGerald

Enabling subcellular DESI-MSI for broad adoption: Acquisition, analysis, and application

This paper demonstrates subcellular mass spectrometry imaging using standard hardware and open-source software, enabling accessible spatial metabolomics with subcellular resolution.

Single-cell transcriptomics reveals cell-type-specific circadian rhythms and their disruption by acute misalignment in mouse aorta

This study uses single-cell RNA sequencing to analyze circadian rhythms in mouse aorta cells and shows how acute misalignment disrupts these rhythms and vascular function.

The Regulation of COX-2, ABCA1 and ABCG1 by the lncRNA PACERR links the inflammatory response and cholesterol homeostasis

This paper identifies PACERR as a lncRNA that regulates COX-2 and cholesterol transport genes, linking inflammation and cholesterol homeostasis through distinct mechanisms in response to HDL and LPS.

Concomitant suppression of COX-1 and COX-2 is insufficient to induce enteropathy associated with chronic NSAID use

The paper shows that suppressing both COX-1 and COX-2 does not cause intestinal injury in mice unless combined with specific NSAIDs, and that gut microbiome changes amplify NSAID-induced enteropathy.

MSI.EAGLE: An Open-Source GUI for Streamlined Mass Spectrometry Imaging Analysis

MSI.EAGLE provides an open-source GUI for MSI analysis, integrating advanced tools to simplify data processing and visualization for non-specialists.

Metabolomic Response to Non-Steroidal Anti-Inflammatory Drugs

This study compares the metabolomic effects of naproxen and celecoxib in humans and mice, finding that naproxen reduces tryptophan levels independently of Cox-2 inhibition.

Brown adipose tissue thermogenesis rhythms are driven by the SCN independent of adipocyte clocks

This study shows that the SCN controls BAT thermogenesis rhythms through sympathetic signaling, independent of adipocyte clocks.

Cyclooxygenase-2 disruption predisposes to heart failure with preserved ejection fraction

This study shows that COX-2 deletion or inhibition leads to heart failure with preserved ejection fraction in zebrafish, mice, and humans.

Disruption of the PGE2 synthesis / response pathway restrains atherogenesis in programmed cell death-1 (Pd-1) deficient hyperlipidemic mice

This study shows that disrupting the PGE2 synthesis or response pathway reduces atherogenesis in PD-1 deficient hyperlipidemic mice through different immune mechanisms.

Disruption of Prostaglandin F2α Receptor Signaling Attenuates Fibrotic Remodeling and Alters Fibroblast Population Dynamics in A Preclinical Murine Model of Idiopathic Pulmonary Fibrosis

This study shows that disrupting PGF2α receptor signaling reduces fibrosis in a mouse model of IPF by altering fibroblast dynamics and reducing fibrotic endpoints.

Deep Phenotyping of the Lipidomic Response in COVID and non-COVID Sepsis

The paper identifies lipidomic biomarkers and therapeutic targets in sepsis patients, including those with COVID-19, and develops an interactive network analysis tool for multiomic data exploration.

Tempo: an unsupervised Bayesian algorithm for circadian phase inference in single-cell transcriptomics

Tempo is a Bayesian method for inferring circadian phase from scRNA-seq data, providing accurate estimates and uncertainty quantification.

Variability in the Analgesic Response to Ibuprofen Following Third-Molar Extraction is Associated with Differences in Activation of the Cyclooxygenase Pathway

This study identifies differences in cyclooxygenase pathway activation and inflammatory biomarker levels as factors associated with variability in ibuprofen analgesic response following third-molar extraction.