PKN2 deficiency leads both to prenatal congenital cardiomyopathy and defective angiotensin II stress responses.
Jacqueline J. T. Marshall, Joshua J. Cull, Hajed Obaid Alharbi, May Zaw Thin, Susanna T.E. Cooper, Christopher Barrington, Hannah Kate Vanyai, Thomas J. A. Snoeks, Bernard M. Siow, Alejandro Suárez‐Bonnet, Eleanor Herbert, Daniel J. Stuckey, Angus J.M. Cameron, Fabrice Prin, Andrew C. Cook, , Peter J. Parker
This study shows that PKN2 deficiency causes prenatal congenital cardiomyopathy and impairs angiotensin II-induced cardiac hypertrophy in adult mice.
Biochemical Journal · Jun 22, 2022Peer-reviewedDevelopmental Biology