Christopher Barrington

This study analyzes ancient genomes from Roman and early medieval Britain to uncover population history, ancestry shifts, and selection patterns shaping modern genetic diversity.

This study identifies a hyper-inflammatory immune response in HIV-associated TB meningitis, marked by cytotoxic CD8 T cells, activated neutrophils, and type 1 interferon signaling.

This study examines how prolonged AHR activation, either through genetic means or environmental pollutants, affects immune responses to intestinal infection, finding differential impacts on infection clearance and immune cell function.

This study generates the first single-cell transcriptomic atlas of marsupial gastrulation and early organogenesis, revealing accelerated transcriptional programs and novel tissues associated with developmental heterochrony.

The paper analyzes ancient Borrelia genomes to document the evolutionary transition from tick-borne to louse-borne transmission and shows rapid reductive evolution.

The paper identifies an intercellular metabolic relay involving glutamine and glutamate that sustains neural stem cell proliferation during brain sparing in Drosophila.

This study uses genomic data from 91 individuals in Ukraine to analyze migration patterns from the Bronze Age to the early modern period, revealing complex ancestry changes and continuity.

This study uses high-resolution genomic ancestry analysis to reveal mobility patterns in early medieval Europe using ancient DNA.

This study shows that chromatin loops form through transcription-driven DNA-DNA capture rather than loop extrusion by cohesin.

The paper shows that dense Rap1 arrays block DNA loop extrusion by condensin in yeast, acting as contact insulators and affecting dicentric chromosome resolution.

This study shows that mouse gastruloids generate PGC-like cells (Gld-PGCLCs) through self-organized interactions, mimicking in vivo PGC development without exogenous signals.

This study shows that PKN2 deficiency causes prenatal congenital cardiomyopathy and impairs angiotensin II-induced cardiac hypertrophy in adult mice.

The paper identifies a novel enhancer that regulates Bdnf expression in developing neurons, increasing mRNA levels and promoting neuronal differentiation and dendritogenesis.

Human embryonic spinal cord scRNA-seq (71,219 cells, CS12-CS19) mirrors mouse patterning and neurogenesis but shows floor-plate PAX7, broad ventral NKX6.2 and early OLIG2/NKX2.2 progenitors.

The paper shows that slower human embryonic development compared to mice is due to higher protein stability and longer cell cycle duration in human cells.