Peter J. Parker

The PRKCA D463H mutation, an inactivating kinase mutation, acts as a gain-of-function oncogenic driver in mice, promoting chondrosarcoma through non-catalytic mechanisms.

The paper reports the structure of aPKC-Par6 bound to Lgl1 and proposes a model for its mutual inhibition and release mechanism in cell polarity.

This study shows that PKN2 deficiency causes prenatal congenital cardiomyopathy and impairs angiotensin II-induced cardiac hypertrophy in adult mice.