TLR2 signaling uniquely destabilizes tumor Tregs to promote cancer immunotherapy
Timothy F. Campbell, Jesse Garcia Castillo, Sebastian Fernandez, Diego Gonzalez Ventura, Jenna Vickery, Stefan Homentcovschi, Nicole Flores Hernandez, Julia Ybarra, Daniel A. Portnoy, Michel J.P. DuPage
This study shows that TLR2 signaling in innate immune cells within tumors reduces Treg stability, enhancing cancer immunotherapy by improving CD8+ T cell function.
bioRxiv · Jun 26, 2025 · PreprintImmunology