Daniel A. Portnoy

This study shows that Listeria monocytogenes evades MAIT cells by lacking riboflavin biosynthesis, and engineered strains that produce riboflavin activate MAIT cells, offering therapeutic potential against infections and cancer.

This study shows the mevalonate pathway in Mycobacterium marinum is dispensable in culture but supports metabolic flexibility under stress and during hypoxia.

This study shows that TLR2 signaling in innate immune cells within tumors reduces Treg stability, enhancing cancer immunotherapy by improving CD8+ T cell function.

This study shows that methylglyoxal, a byproduct of aerobic glycolysis in infected macrophages, acts as an antimicrobial effector that enhances host defense against bacterial pathogens.

This study shows phosphorylation at specific residues on stressosome proteins dictates assembly, activation, and function in Listeria monocytogenes, with implications for virulence and antimicrobial targets.

This study investigates how different routes of Listeria monocytogenes administration affect tumor growth in mice, finding that IV followed by IT administration controls tumor growth through anti-Lm CD8 T cells.