Interprotomer Communication and Functional Asymmetry in H/ACA snoRNPs
Hemendra Singh Panwar, Timothy John Vos, Xiaoyan Xie, H. Josh Jang, Hyoungjoo Lee, Ryan D. Sheldon, Evan J. Worden, Ute Kothe
This study presents cryo-EM structures of active H/ACA snoRNPs, revealing inter-protomer interactions and how mutations affect pseudouridine formation and ribosome biogenesis.
Proceedings of the National Academy of Sciences · Dec 18, 2025Peer-reviewedBiochemistry