Author

Ute Kothe

University of LethbridgeORCID 0000-0002-2744-7334Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Assay:DNA methylation· 2 Organism:E. coli· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

Sarah K. SchultziD· 2 shared Abeer Abdullah Ogailan· 1 shared Anne C. Rintala‐DempseyiD· 1 shared Christopher D. KatanskiiD· 1 shared Evan J. WordeniD· 1 shared H. Josh JangiD· 1 shared Hemendra Singh PanwariD· 1 shared Hyoungjoo LeeiD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersBiochemistry

Sarah K. SchultzORCID

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4 papers

Recent·Most cited

The tRNA dihydrouridine synthase DusA has a distinct mechanism in optimizing tRNAs for translation

Sarah K. Schultz, Nadia Hossain, Lauren Barnes, Tirathjot Kaur, Kristin S. Koutmou, Ute Kothe

This study investigates the role of DusA in tRNA modification and translation, finding it selectively enhances specific tRNA charging and translation at certain codons.

Nucleic Acids Research · Apr 23, 2026Peer-reviewedBiochemistry

Interprotomer Communication and Functional Asymmetry in H/ACA snoRNPs

Hemendra Singh Panwar, Timothy John Vos, Xiaoyan Xie, H. Josh Jang, Hyoungjoo Lee, Ryan D. Sheldon, Evan J. Worden, Ute Kothe

This study presents cryo-EM structures of active H/ACA snoRNPs, revealing inter-protomer interactions and how mutations affect pseudouridine formation and ribosome biogenesis.

Proceedings of the National Academy of Sciences · Dec 18, 2025Peer-reviewedBiochemistry

Modifications in the T arm of tRNA globally determine tRNA maturation, function and cellular fitness

Sarah K. Schultz, Christopher D. Katanski, Mateusz Hałucha, Noah Peña, Richard P. Fahlman, Tao Pan, Ute Kothe

This study shows that tRNA modifications in the T arm by TrmA and TruB are essential for tRNA maturation, aminoacylation, and translation, enhancing cellular fitness in E. coli.

Proceedings of the National Academy of Sciences · Jun 18, 2024Peer-reviewedMolecular Biology

Saccharomyces cerevisiae strains display robust phenotypes in the presence of Dyskeratosis congenita mutations in the Cbf5 gene

Abeer Abdullah Ogailan, Anne C. Rintala‐Dempsey, Ute Kothe

This study introduces Dyskeratosis congenita mutations into yeast to assess their impact on ribosome biogenesis and cellular fitness, finding no significant growth defects.

bioRxiv · Jan 30, 2019 · PreprintMolecular Biology