Hyoungjoo Lee

This study shows that SATB2 and circ3915 RNA chromatin dysregulation can drive KRAS-like oncogenic transformation in lung epithelial cells without driver mutations.

This study presents cryo-EM structures of active H/ACA snoRNPs, revealing inter-protomer interactions and how mutations affect pseudouridine formation and ribosome biogenesis.

This study shows that tau filament seeding capacity depends on both core structure and phosphorylation in the fuzzy coat, with phospho-mimetic residues restoring activity in modified tau.

This study identifies glucose-dependent glycosphingolipid biosynthesis as essential for CD8+ T cell expansion and tumor control, independent of energy production.

This study identifies the KEAP1-NRF2 pathway as a driver of CD8 T cell exhaustion by regulating the prostacyclin receptor PTGIR.

The paper identifies a role for oocyte mitochondrial electron transport chain remodeling in linking maternal environment to offspring metabolism and survival.

The paper shows that metabolite extracts contain active enzymes and demonstrates a new workflow to remove proteins for improved metabolomics.