Author

David Melzer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 2 Genomics· 2

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 4 Assay:bulk RNA-seq· 2 Research Focus:GWAS / association mapping· 2 Research Focus:benchmarking· 1 Research Focus:differential expression· 1 Research Focus:eQTL / molecular QTL mapping· 1 Assay:GWAS summary statistics· 1

Frequent Co-Authors

Luigi FerrucciiD· 4 shared Hanieh YaghootkariD· 2 shared Lorna W Harries· 2 shared Samuli RipattiiD· 2 shared Thomas MeitingeriD· 2 shared Aarno V. PalotieiD· 1 shared Adrew R. Wood· 1 shared Alan Kwong· 1 shared

Activity by Year

2014-2018 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersGenetics

Luigi FerrucciORCID

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4 papers

Recent·Most cited

Narrow-sense heritability estimation of complex traits using identity-by-descent information.

Luke M. Evans, Rasool Tahmasbi, Matthew Jones, Scott I. Vrieze, Gonçalo R. Abecasis, Sayantan Das, Douglas W. Bjelland, Teresa R de Candia, David Altshuler, Carl A. Anderson, Andrea Angius, Jeffrey C. Barrett, Sonja I. Berndt, Michael Boehnke, Dorrett Boomsma, , George Davey Smith

This paper estimates narrow-sense heritability using identity-by-descent information in unrelated individuals and finds that IBD-based methods can capture rare variant contributions but are affected by stratification.

Heredity · Mar 28, 2018Peer-reviewedGenetics

The reported healthy ageing gene expression score: lack of association in two cohorts

Luke C. Pilling, Lorna W Harries, Dena G Hernandez, Andrew B Singleton, George A. Kuchel, Luigi Ferrucci, David Melzer

The study tests a reported healthy ageing gene expression score in two cohorts and finds no association with age or related phenotypes.

bioRxiv · Feb 19, 2016 · PreprintGenomics

HUMAN LONGEVITY IS INFLUENCED BY MANY GENETIC VARIANTS: EVIDENCE FROM 75,000 UK BIOBANK PARTICIPANTS

Luke C Pilling, Janice L Atkins, Kirsty Bowman, Samuel E Jones, Jessica Tyrrell, Robin N Beaumont, Katherine S Ruth, Marcus A Tuke, Hanieh Yaghootkar, Andrew R Wood, Rachel M Freathy, Anna Murray, Michael N Weedon, Luting Xue, Kathryn Lunetta, , David Melzer

This study identifies genetic variants associated with parental longevity using GWAS on 75,000 UK Biobank participants, finding multiple protective factors linked to longer lifespan.

bioRxiv · Feb 1, 2016Genomics

Cell specific eQTL analysis without sorting cells

Harm-Jan Westra, Danny Arends, Tõnu Esko, Marjolein J. Peters, Claudia Schurmann, Katharina Schramm, Johannes Kettunen, Hanieh Yaghootkar, Benjamin Fairfax, Anand Kumar Andiappan, Yang Li, Jingyuan Fu, Juha Karjalainen, Mathieu Platteel, Marijn Visschedijk, , Dena

The paper introduces a method for cell-specific eQTL analysis without cell sorting, showing that Crohn's disease-associated SNPs mainly affect neutrophil gene expression in whole blood data.

bioRxiv · Feb 12, 2014Genetics