TEAD inhibition alters the lung immune microenvironment and attenuates metastasis.
Raneen Rahhal, Marcel O. Schmidt, Maha Moussa, Tina Asemi, Rohith Battina, Amber J. Kiliti, Anton Wellstein, Anna Tate Riegel, Ghada M. Sharif
This study shows TEAD inhibitors reduce lung metastases by altering immune signaling, enhancing anti-tumor immune responses, and changing macrophage and T-cell interactions.
bioRxiv · Feb 26, 2025 · PreprintCancer Biology