Maha Moussa

Tumor intrinsic regulation of PD-L1 and of interferon Type I via an SLC25A1-driven mitochondrial pathway, influences the anti-tumor immune response

This study identifies SLC25A1 as a regulator of PD-L1 and type I interferon signaling via a mitochondrial pathway, influencing tumor immune response and immunotherapy efficacy.

TEAD inhibition alters the lung immune microenvironment and attenuates metastasis.

This study shows TEAD inhibitors reduce lung metastases by altering immune signaling, enhancing anti-tumor immune responses, and changing macrophage and T-cell interactions.