Behavior-coupled single-cell transcriptomics reveals trafficking protein-dependent regulation of tumor cell migration
Reza Ghadiri Rad, Junfeng Huang, María Teresa López-Cascales, Li You, Joleen J.H. Traets, Domenico Bellomo, Ting-Chun Chou, Wesley Bennik, Jasmin Singh, Yasin Begce, Jose Angelito U Hardillo, Disha Vadgama, Thierry van den Bosch, Thierry P. P. van den Bosch, Miao‐Ping Chien
This study introduces BC-seq, a method linking migratory behavior to transcriptomics in cancer cells, identifying molecular programs associated with aggressive migration and a predictive gene signature for metastasis.
bioRxiv · Oct 16, 2026 · PreprintCancer Biology