María Teresa López-Cascales

Behavior-coupled single-cell transcriptomics reveals trafficking protein-dependent regulation of tumor cell migration

This study introduces BC-seq, a method linking migratory behavior to transcriptomics in cancer cells, identifying molecular programs associated with aggressive migration and a predictive gene signature for metastasis.

Unraveling the molecular mechanisms underlying spontaneous multipolar mitosis through CIN-seq

The paper develops CIN-seq to study rare multipolar mitosis in cancer cells, revealing genomic instability and new mechanisms of adaptation to chromosomal instability.

ARID1A-BAF coordinates ZIC2 genomic occupancy for epithelial to mesenchymal transition in cranial neural crest lineage commitment

The paper shows ARID1A-haploinsufficiency impairs EMT in CNCC specification by disrupting ARID1A-BAF binding at EMT enhancers, which affects ZIC2 occupancy and leads to aberrant neuronal gene activation.

Optimal frequency of perinatal retinal waves is essential for the precise wiring of visual axons in non-image forming nuclei

This study shows that spontaneous retinal waves before visual experience shape connectivity in non-image forming nuclei by analyzing transcriptomic profiles of RGCs in mice.

Zic2 abrogates an alternative Wnt signaling pathway to convert axon attraction into repulsion

The paper identifies an alternative Wnt signaling pathway regulated by Zic2 that mediates axon repulsion by modulating β-catenin phosphorylation and Eph signaling.

Immediate and deferred epigenomic signature of neuronal activation

The paper investigates transcriptional and chromatin changes in hippocampal neurons during and after activation, identifying immediate and long-term epigenomic signatures linked to neuroplasticity.