Miao‐Ping Chien

Behavior-coupled single-cell transcriptomics reveals trafficking protein-dependent regulation of tumor cell migration

This study introduces BC-seq, a method linking migratory behavior to transcriptomics in cancer cells, identifying molecular programs associated with aggressive migration and a predictive gene signature for metastasis.

Unraveling the molecular mechanisms underlying spontaneous multipolar mitosis through CIN-seq

The paper develops CIN-seq to study rare multipolar mitosis in cancer cells, revealing genomic instability and new mechanisms of adaptation to chromosomal instability.

Plasmonic Enhancement of Protein Function

This study demonstrates plasmonic enhancement of protein function in living cells by coupling designed nanoparticles to Archaerhodopsin proteins, increasing fluorescence and response speed.

Two-photon photoactivated voltage imaging in tissue with an Archaerhodopsin-derived reporter

The paper develops a novel genetically encoded voltage indicator, NovArch, enabling high-resolution voltage imaging in brain tissue with improved sensitivity, background rejection, and time resolution.