Spatiotemporal NF-κB dynamics encodes the position, amplitude and duration of local immune inputs
Minjun Son, Tino Frank, Thomas Holst‐Hansen, Andrew G. Wang, Michael Junkin, Sara Saheb Kashaf, Ala Trusina, Savaş Tay
The paper shows that NF-κB dynamics in fibroblasts encode cytokine dose, duration, and distance through wave-like propagation, creating spatially defined gene expression zones.
Science Advances · Aug 31, 2022Peer-reviewedSystems Biology