Savaş Tay

This paper introduces Sprox-seq, a multi-omic technique that maps protein interactions and mRNA in human germinal centers, revealing distinct B cell maturation pathways and spatially-enriched immune regulatory complexes.

The paper introduces a microfluidic system to study antibiotic responses in 3D cultures, revealing synergy, antagonism, and order-dependent drug efficacy.

This study shows single macrophages can accurately detect and respond to short-lived immune signals through receptor cooperativity and pathway variability.

The paper introduces a physical model and improved analysis methods for quantifying protein complexes from Prox-seq data, enhancing accuracy and robustness.

The paper shows that NF-κB dynamics in fibroblasts encode cytokine dose, duration, and distance through wave-like propagation, creating spatially defined gene expression zones.

The paper shows that NF-κB memory affects how cells respond to subsequent inflammatory stimuli based on prior signal history.

The paper introduces FD-seq, a method for single-cell RNA sequencing of fixed cells, and applies it to study virus infection and host response in rare cell populations.

The paper shows NF-κB differentiates cytokine input doses by using negative feedback loops to track changes in concentration rather than absolute levels.

This study uses deep learning and live-cell analysis to show that NF-κB activation in single cells is pre-determined by pre-stimulation nuclear localization ratios of NF-κB to IκB.