Tom Collet

Replacing In Vivo Experiments for PK/PD Target Determination Through In Vitro Time-Kill Experiments and PK/PD Modelling Incorporating Inter-strain Variability: Application to Meropenem Against Pseudomonas aeruginosa

This paper demonstrates that in vitro time-kill experiments with pharmacometric modeling can identify PK/PD targets equivalent to animal models for meropenem against P. aeruginosa, while quantifying inter-strain variability.

Optimizing Antimicrobial Susceptibility Testing: Cost and Environmental Benefits of MIC Volume Reduction

This study shows that reducing MIC assay volumes in antimicrobial testing maintains accuracy while lowering costs and environmental impact, except for micafungin.