Julien M. Buyck

This paper demonstrates that in vitro time-kill experiments with pharmacometric modeling can identify PK/PD targets equivalent to animal models for meropenem against P. aeruginosa, while quantifying inter-strain variability.

The paper evaluates TAPs transfer kinetics and resensitization efficiency in E. coli using a mechanistic model of subpopulation dynamics, finding plasmid delivery is the main bottleneck.

This study measures zeta potential in E. coli to assess colistin susceptibility and uncover resistance mechanisms by linking surface charge changes to antibiotic resistance.

This study shows that reducing MIC assay volumes in antimicrobial testing maintains accuracy while lowering costs and environmental impact, except for micafungin.