Centromere protection requires strict mitotic inactivation of the Bloom syndrome helicase complex
María Fernández-Casañas, Eleftheria Karanika, Umit Aliyaskarova, Tomisin Olukoga, Alex D. Herbert, Antony W. Oliver, Matthew Day, Adrijana Crncec, Kok‐Lung Chan
This study identifies a centromere protection pathway in human mitotic cells that relies on strict mitotic inactivation of the BTRR complex through phosphorylation and kinase regulation.
Nature Communications · Aug 22, 2025Peer-reviewedCell Biology