Alex Herbert

The Greatwall/PP2A-B55α axis remodels the G2/M boundary and shapes cellular dependence on PKMYT1

The paper investigates how perturbations of the CDK1-Greatwall-PP2A-B55 feedback loop affect cell-cycle control in different cell types, finding that PP2A-B55 acts as a context-dependent G2/M repressor and that cancer cells show specific sensitivities to PKMYT1 inhibitors.

The Balance between B55α and Greatwall expression levels predicts sensitivity to Greatwall inhibition in cancer cells

This study shows that the balance between B55α and Greatwall expression levels determines cancer cell sensitivity to Greatwall inhibition.

Centromere protection requires strict mitotic inactivation of the Bloom syndrome helicase complex

This study identifies a centromere protection pathway in human mitotic cells that relies on strict mitotic inactivation of the BTRR complex through phosphorylation and kinase regulation.

Live-cell single-molecule tracking highlights requirements for stable Smc5/6 chromatin association in vivo

The paper uses live-cell single-molecule tracking in fission yeast to show that Smc5/6 chromatin association depends on Nse6 and specific sub-pathways, with implications for homologous recombination.