Gβγ engages PLCβ3 at multiple sites to reorient and facilitate its activation
Isaac J. Fisher, Kanishka Senarath, Kennedy Outlaw, Kaushik Muralidharan, Elisabeth E. Garland-Kuntz, Michelle M. Van Camp, Tommy Komay, Leon F. Laskowski, Asuka Inoue, Evi Kostenis, Nevin A. Lambert, Angeline M. Lyon
This study shows Gβγ enhances PLCβ3 activation by reorienting its catalytic site, working with Gq to increase PI(4,5)P2 hydrolysis and Ca2+ release.
bioRxiv · Jul 1, 2026Biochemistry