Thalamus-cortex interactions drive cell type-specific cortical development in human pluripotent stem cell-derived assembloids
Masatoshi Nishimura, Shota Adachi, Tomoki Kodera, Akinori Sato, Ryosuke F. Takeuchi, Fumitaka Osakada
This study uses human thalamocortical assembloids to show that thalamus-cortex interactions drive cell type-specific cortical development through gene expression, circuit organization, and activity patterns.
Proceedings of the National Academy of Sciences · Nov 17, 2025Peer-reviewedNeuroscience