Itaru Hamachi

The paper introduces DMD-PhoxID, a method for mapping protein-proximity interactions in fixed brain tissue with subanatomical resolution using patterned photocatalytic labeling.

This paper introduces NARCH, a chemogenetic method to reversibly inhibit endogenous receptors in specific cell types in vivo, demonstrating its use in studying mGlu1 signaling in Purkinje cells.

This paper introduces tmPhoxID, a method to label the cytoplasmic side of transmembrane proteins using singlet oxygen, and demonstrates its application in identifying intracellular interactomes of specific receptors in the mouse brain.

This study develops semisynthetic biosensors to quantitatively map synaptic zinc dynamics in the mouse brain with synapse-level resolution.

This paper identifies PPTD, the first selective ZIP14 inhibitor, showing it reverses ZIP14-driven cytotoxicity and ameliorates cancer cachexia in mice.

The paper develops a method to modify receptor proteins in the living mouse brain with fluorescent probes using ligand-directed and click chemistry, enabling high-resolution mapping of matrix metalloproteinase-9 activity near AMPARs.

This study introduces Porp-L, a conditional proteomics tool for labeling ONOO--reactive proteins, and identifies new roles for Ero1a in ONOO- formation and ER as an ONOO- hotspot.

This study shows that an archaeal SMC complex forms TAD-like domains and is stalled by TrmBL2, with stalling efficiency linked to DNA structure.

This study shows that human cortical organoids develop functional synapses with AMPA receptors, transitioning from silent synapses to active ones as they mature.

This paper introduces a chemical probe for visualizing AMPA receptors in living neurons without genetic modification, revealing synaptic plasticity mechanisms.

This study maps native surface AMPAR organization in mouse brain regions and tauopathy models using dSTORM imaging, revealing regional differences and early synaptic remodeling in tauopathy.

This paper introduces PhoxID, a light-activated proximity labeling method to study receptor interactomes in live mice with minute-order temporal resolution.

This paper develops a chemogenetic method to selectively activate mGlu1 receptors in brain tissue using a palladium complex and a mutant receptor, demonstrating its role in synaptic plasticity.

The paper introduces FixEL, a method to trap and image small molecules in brain tissue, enabling visualization of their distribution and dynamics.