Hiroshi Nonaka

This paper introduces NARCH, a chemogenetic method to reversibly inhibit endogenous receptors in specific cell types in vivo, demonstrating its use in studying mGlu1 signaling in Purkinje cells.

This study develops semisynthetic biosensors to quantitatively map synaptic zinc dynamics in the mouse brain with synapse-level resolution.

The paper develops a method to modify receptor proteins in the living mouse brain with fluorescent probes using ligand-directed and click chemistry, enabling high-resolution mapping of matrix metalloproteinase-9 activity near AMPARs.

This study shows that human cortical organoids develop functional synapses with AMPA receptors, transitioning from silent synapses to active ones as they mature.

This study maps native surface AMPAR organization in mouse brain regions and tauopathy models using dSTORM imaging, revealing regional differences and early synaptic remodeling in tauopathy.

This paper introduces PhoxID, a light-activated proximity labeling method to study receptor interactomes in live mice with minute-order temporal resolution.

This paper develops a chemogenetic method to selectively activate mGlu1 receptors in brain tissue using a palladium complex and a mutant receptor, demonstrating its role in synaptic plasticity.

The paper introduces FixEL, a method to trap and image small molecules in brain tissue, enabling visualization of their distribution and dynamics.