Fumitaka Osakada

Membrane progesterone receptors PAQR6 and PAQR8 in the ruminant uterus and ovary

This study maps the expression of PAQR6 and PAQR8 in ruminant reproductive tissues using antibodies and qPCR, showing their localization and dynamic gene expression changes during pregnancy.

Cell-type-specific expression of classical and membrane progesterone receptors at the human maternal-fetal interface

The paper identifies cell-type-specific expression patterns of classical and membrane progesterone receptors at the human maternal-fetal interface using single-cell and spatial transcriptomic data.

Maternal progesterone signaling establishes lifelong oral homeostasis

This study identifies maternal progesterone signaling through mPRδ as critical for establishing lifelong oral homeostasis via a hormone-lipid-microbiome axis.

Thalamus-cortex interactions drive cell type-specific cortical development in human pluripotent stem cell-derived assembloids

This study uses human thalamocortical assembloids to show that thalamus-cortex interactions drive cell type-specific cortical development through gene expression, circuit organization, and activity patterns.

Asymmetric cortical projections to striatal direct and indirect pathways distinctly control actions

The paper shows that corticostriatal projections to D1- and D2-SPNs are asymmetrically overlapping and that pathway-specific subcircuits control distinct behaviors.

MeCP2 controls dendritic morphogenesis via miR-199a-mediated Qki downregulation

This study identifies the MeCP2/miR-199a/Qki axis as critical for dendritic development and shows its dysregulation contributes to dendritic pathology in Rett syndrome.

Maternal progesterone and adipose mPRε in pregnancy regulate the embryonic nutritional state

This study shows that maternal progesterone and adipose mPRε regulate the embryonic nutritional state by affecting glucose provision and metabolic outcomes in offspring.

Bridge protein-mediated viral targeting of cells expressing endogenous μ-opioid G protein-coupled receptors in the mouse and monkey brain

The paper develops a nontransgenic method using bridge proteins to target viral vectors to cells expressing endogenous μ-opioid receptors in mouse and monkey brains.

Conversion of silent synapses to AMPA receptor-mediated functional synapses in human cortical organoids

This study shows that human cortical organoids develop functional synapses with AMPA receptors, transitioning from silent synapses to active ones as they mature.

Layer Va neurons, as major presynaptic partners of corticospinal neurons, play critical roles in skilled movements

The paper identifies layer Va neurons as major presynaptic partners of corticospinal neurons and shows their critical role in skilled movements.

Modeling the marmoset brain using embryonic stem cell-derived cerebral assembloids

This paper develops an in vitro marmoset brain model using cerebral assembloids to study neural development and activity.

Posteromedial cortical networks encode visuomotor prediction errors.

The paper investigates how prediction errors are processed hierarchically in the mouse cortex using virtual reality and identifies a role for Bayesian inference in modeling mismatch responses.